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The reduction of carbohydrates puts the body into a metabolic state called ketosis. This is the problem with the keto diet, it is too restrictive, and when the body is deprived of a certain nutrient, it experiences various reactions some of them being disrupted T3 production. The activation by phosphorylation of PGC1 may occur in several ways involving AMPK, calcium calmodulin dependent protein kinase, and p38 mitogen activated protein kinase pathways. You might be following a keto diet, but that doesn t mean avocado toast is out of reach.