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Rare side effects of all PDE5 inhibitors include a sudden loss of vision in one or both eyes nonarteritic anterior ischemic optic neuropathy and sudden loss of hearing. The most common are some antidepressants beta blockers such as propranolol, atenolol, etc some water tablets cimetidine. These appear finely tuned to detect variability in circumference, whereas the vagina is less sensitive to differences in other stimuli such as vibration or warmth.